NBC's promotional material states that in the show:
* Henry Spivey (Christian Slater) is a middle-class efficiency expert living a humdrum life in the suburbs with a wife, two kids, a dog, and a minivan. Edward Albright is an operative who speaks 13 languages, runs a four-minute mile, and is trained to kill.... Henry and Edward are polar opposites who share only one thing in common—the same body. When the carefully constructed wall between them breaks down, Henry and Edward are thrust into unfamiliar territory where each man is dangerously out of his element. My Own Worst Enemy explores the duality of a man who is literally pitted against himself, a la Dr. Henry Jekyll and Mr. Edward Hyde. And it raises the question: who can you trust when you can't trust yourself?