Greetings all,
I would like to take a step back (been away for some days) to the early of the topic about the MS activation.
To try to not write much and becoming boring, ill first start with the situations that have made me believe in a new theory about MS awakening.
In Sasuke's case, his MS activated in the battle against Itachi, but he never delivered the final blow, he fought to kill him sure, but what demeaned Itachi's loss, was the fact that his body couldn't take it anymore due to his long term illness (witch he knew and planned the fight according to that).
Even in Itachi's case, when he show's the truth to Sasuke, we only see Sishiu giving his eye to Itachi, we never have any proof that Itachi did in fact kill him.
Now, in this chapter, we have the confirmation that both Kakasi and Obito, activate their MS, because the death of Rin (their respective best friend at that time), but again, Obito only watched Rin die (like to previous examples), only Kakashi does reality (in all
manga) to the words "you have to kill your best friend".
Sometime ago, in a galaxy far far away.... nah just kidding, but really sometime ago, i came to a theory because, in the Sharigan users that we know, only Kakashi did really kill a best friend, but in all others, we assume that because of those words, but they only watched (that we know for sure) their friends die, they didn't kill them.
I believe that the words "you have to kill your best friend", are a metaphor/riddle to the real meaning of that idea,
you have to experience/watch the death/loss of your best friend/loved one.
If you think about it, it makes sense, Sasuke looses his brother, Itachi his best friend, Obito is loved one, and Kakashi is best friend also.
So why would the words be like that and not, you have to see the person die ? well, what would happen if your best friend/loved one was sent on a different mission, in another team/squad and died ? it would be the loss of a dear one, but MS wouldn't activate because the user wouldn't be present to see the other one die.
So the only way to be sure MS activates when the closest person to you dies, and you watch it, is to kill that person yourself, but i do not believe that, the killing yourself part is extremely a requirement, only that you witness that.
The first plausible flaw i could think was Sasuke parents (in the very far likelihood that an uchiha could activate Sharingan and MS in the same moment or experience, but Sasuke really doesn't see his parents die, they are already dead when he arrives at home
Just my 2 cents, but open to flaws or discussion
About the vision loss of MS, i think that Kakashi hasn't lost so many like Itachi or Sasuke (before EMS), his due to the fact that he always in his life (since he had the sharigan), train and disciplined himself to rely in his skills and chakra capacity and therefore using only the eye when he really need it, because using the sharigan consumes chakra, and that's why he has it covered all the time.
In the MS case, when the eyes perform a MS technique, the eye is put to some strain due to the power of that technique, and normally, when the user, uses MS is in "big style" like Susano'o, Amaterasu, Tsukuyomi or any other powerfull MS related tech.
In Kakashi's case, his Kamui's are always in small things/objects like kunais, rasengans, and those were in the last few chapters, even when he tried it on Deidara, he was some distance away, and the far the object his, the smaller it appears to be and the harder is hit it good.
The same could apply to GM neck, but that depends on the distance Kakashi is from it, but still, ony that and the
naruto clone, arent enough to deteriorate his vision like Itachi or Sasuke, and the eye's vision only looses his sight from MS use, i think that Itachi says that in some chapter i think, so a normal sharigan doesnt loose his eye sight, because not anyone activates MS, witch is suppose to be a secret of the Uchiha and not comum knowledge, unless all the Uchiha clan become blind people, sharigan or MS users lol lol
Just my point of view

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