hmm its just a quick thought - and not much thought put into it but basically;
it seems sasuke has achieved his goal killing his brother - although he still wants to kill madara'
Two of the sannin are dead, well might as well be, orochimaru and jiraya, and naruto seems to be generation based- so in my opinion tsunade will die somehow.
If Sasuke has achieved his goal it seems naruto will keep up with him and become hokage which makes sense with the sannin dying.
hmm but idk naruto still seems a bit crap for hokage