Based on Where we are so far Where do you see the Comic going as of now?
My idea is ...
-Sasuke may Realize that w/o EMS he may not stand a chance against Madara and take Itachi's eyes but not use them yet. He will build his own small army to counter Akatsuki.
-That later on Dan will Indirectly lead to Tsunade death thru either Oro-Kabuto or Akatsuki. Maybe Naruto gets caught and she will risk it all to save him and die in battle but rescue him.
-Konha may be at the brink of war perhaps with no Kage; another country may attempt to attack do to info leaked by Akatsuki or Dan himself.
-With Tsunade dead a 6th Hokage must be choosen and Dan volunteers (I see him sceaming his way to the top). Kakashi is also a canidate but maybe with Konha at the brink of war its decided that the need a Kage with more experiance.
-Dan becomes 6th Hokage and next great ninja war begins. He begins tweaking and undoing little by little the work that the previous Hokage's in his new reforms.
He may openly declare Sasuke an enemy of Konha and to be captured dead or alive.
( It would be intresting if Dan became Hokage cause now they would be dealing with the enemy within as well as the real external forces.)
I think at about the time the time Dan becomes the 6th and the war begins this would be a good point for a time skip.
-A world wide ninja war would be great for Akatsuki because if what Pein told Jiriaya was true they would have an opportunity to promise those "Bujuu weapons" to other countries.