Caesar said it doesn't like water, and the G-5 guy stated that was all they had to do as well (though I'm assuming it was the most logical assumption he had at the time seeing as he couldn't have known); unless we come to know ice now reacts in some way with Slime, much like fire causes it to explode, then we can't say freezing affects it whatsoever. Regardless, we know it emits gas when provoked/hunting?, is rather intelligent or concious of its surroundings, and of course explodes when lit on fire.

Which again, does anyone have any ideas as to why Slime didn't explode and destroy half the island while it crossed the Fire Lands???