Here's what i think will happen, sasuke will turn evil after defeating Itachi or Tobi, since there's no way he's ever coming back to konoha. Naruto will be forced to kill Sasuke and then go on to become Hokage. I wouldn't mind if naruto died honorably in a great battle but it'll have to be after he has become hokage and has fathered few children with sakura/hinata. Or naruto becomes hokage first and then both sasuke and naruto die together in a huge final climactic battle.
And btw, Tsunade wore that necklace and she ain't dead yet.