Hi Guys, I have been following you for a long time and decided to write my very first post to discuss this key chapter. I gave a 5/5 for this chapter because Izanami was finally revealed.
According to Itachi, Kabuto is now trapped in an infinite loop which looks like the "groundhog day" movie great movie by the way)! Also, Itachi kept talking in many chapters about fate and destiny and how it changed its views in the ninja world. This leads to the beauty of Izanami. I strongly believe the person who is trapped in Izanami can only exit if he performs certain actions or takes decisions chosen by the justu caster. Once the actions or decisions are fullfilled then it becomes reality! Hence, Kabuto will only escape if he decides to change his destiny by performing the hand seals to undo zombi-mode. Clearly, Izanami is the strongest genjutsu in Narutoverse since the caster will decide the fate or destiny of the castee.
This being said, I come back to my statement about why this is a key chapter.
1- How come a single-use jutsu such as Izanami is known by Itachi? Jutsus are typically only acquired through experience unless I am wrong.
2- Have you always wondered why Itachi wiped out his entire clan (children included) based on the motives his father and fellows were planning a coup.
I strongly believe that 1 is related to 2 because Itachi's fate was chosen when he was himself trapped by Izanami. Who would be the best character to do such an advanced jutsu? The masked man with a missing left eye would be a good answer. He wanted to wipe the whole clan for revenge purposes without being accused of it and was Itachi's master at some point.
I know this would raise up more questions than actually solve ones (for example, why Sasuke was the only survivor).