Blame is created by Tsutomu Nihei
Killy, a silent loner possessing an incredibly powerful weapon known as a Gravitational Beam Emitter, wanders a vast technological world known as "The City". He is searching for Net Terminal Genes, a (possibly) extinct genetic marker that allows humans access to the Netsphere. "The City" is an endless vertical space of walls, stairways and caverns, and separated in some kind of "floors" composed of several thousand of levels and divided by nearly-impenetrable structures known as "Megastructure" that separate entire floors or sections of "The City". "The City" is inhabited by scattered human and transhuman tribes as well as hostile cyborgs known as Silicon Creatures. The Net Terminal Genes appear to be the key to halting the unhindered, chaotic expansion of the Megastructure, as well as a way of stopping the murderous horde known as the Safeguard from destroying all humanity.
Along the way, Killy meets and joins forces with a resourceful engineer named Cibo and a tribe of human warriors called the Electro-Fishers. They are pursued by the Safeguard, who view any human without Net Terminal Genes as a threat to be extinguished on sight.
Blame! features extremely dark, highly detailed depictions of the fantastic, ever-changing world of The City, punctuated by brutal combat. There is generally little dialogue to support the action or story, and the reader is left to piece together the plot for themselves. Many scenes are spent on the long, lonely travels through The City.