She/they was/were alive when Hashirama and Mito were alive. Tsunade and Jiraiya are older than Kushina, and we know that at least Mito was still alive when she was brought to the village. The jury's out on whether Hashirama was still alive as well (part of me doubts it). Anyway, I doubt Tsunade would have received any special information about they Uzumakis beyond what was already known. They weren't world renown shinobi back then just yet (I think).
Originally Posted by paulbee