In the Arc where Shikamaru Killed The Zombie guy, he said that the land where he buried Hidan was an Isolate forest that only members of the Nara clan ever visited. This reference does not prove Tobirama's purity one way or another, but it does tend to cement the fact that other Clans had areas Isolated for their exclusive use.
There is no doubt that Tobirama distrusted the Uchiha and kept an eye on them, BUT I have yet to recollect an actual act of Malice from Tobirama to the Uchiha. He did not harras them, did not imprison them, did not forbid them from town, or from participating in missions.
I will go as far as to say that Tobirama's bigotry was mainly in his mind and attitude, and not in the things he did. I'll subscribe to this view until some new acts come out that show Tobirama actually performing an act of harm on the Uchiha.
In the end, It was an Uchiha afteral that brought the Kyuubi into Konoha, and this suspiscion is what made Konoha even more distrusting of Uchihas.