Real life problems characterized in Naruto
I think that chapter 373 begins to closely resemble some of the harsh realities of the world such as the collatoral damage caused by wars, manipulation of nations by diplomacy (derives from some Chiyo statements), and fighting other people just because the other is weaker.
The part where Jiraiya helped out the three kids told quite a bit of the tortures of typically senseless wars. Notice how Orochimaru reacts to the three kids. He says something like: we should kill them to save them from the terrible life associated with being orphaned. It is true the orphan life is a tough life. Living in the middle of a war zone only worsens the situation. Imagine too not having a father and mother to help you throughout life and "be there".
Of course, so many parts of Naruto feature a real life connection, but I want to see what kind of comment you have.