The game changer will be whatever revelations sasuke will have from orochimaru facilitating their meeting with the progenitor /human who knows everything. I think it will bring about significant changes to sasuke's attitude and mentality which began after the edo itachi experience had finished. It will mean naruto will have to alter his approach to sasuke either in degree of intensity or in angle of appreciation.
Orochimaru has little to offer the story after the meeting concludes. Kabuto, having became a new so6p being (obviously incomplete and unique in execution, lacking the uchiha and senju combination of components), kabuto having done that has replaced the story's need and focus on orochimaru obtaining sasuke's body or sharingan. It's kabuto's game now and if any snake is to take a sharingan it should be him, otherwise, it will be too tacky and matter of oversaturation concerning eye transplants among too many characters.
So, for sake of asking a question, will kabuto reappear after the izanami finishes? In what new way will he see himself and his destiny? Most importantly, will he advance his transformation into the 4th so6p?
Oro does not need Sasuke's body, he can simply Grow His own Sasuke that's already infused with Hashirama's cells, but lacking a soul in it.
apologies to anybody who already brought this up!
so, guys.. i found something interesting in my rereading...
kabuto used juugo cells to assist his access to sage mode. if that isn't the case, at the very least kabuto explained that juugo's clan's special ability is for their bodies to naturally utilize natural energy as a type of sage chakra to enhance their bodies and it was explained to be an ability granted them somehow by the dragon sage kabuto trained under. it's what allowed orochimaru to develop the cursed seal and is also why juugo can empathize and communicate with birds and animals.
now, sasuke was compatible with the cursed seal. furthermore, and this is most important ... when killer bee used lariat to counter sasuke after escaping his ms genjutsu the attack end follow up blow totally annihilated sasuke's neck and chest. juugo (now THIS is the important part) healed sasuke with his own flesh since uzumaki chakra of karin was insufficient. sasuke's chest and neck is literally juugo's body!
do you think that having endured the experience of cursed seal and later recieving juugo's cells that sasuke will have his own sage mode or refined ability to gather natural energy apart from his old cursed seal (that had limitations)?
keep in mind that the manga has given precedent with using partial body grafting to add powers. danzo, madara, obito, and kabuto all obtained powers not their own by using cells and body parts of other shinobi (hashirama all over the place). sasuke having juugo cells is no different! !
best evidence: obito and sasuke had their bodies healed in the EXACT SAME WAY! obito took hashirama flesh amd gained mokuton as a result!
kishi is cleverly hiding this and saving it for later and sasuke hasn't put it together yet!
so, will having juugo's cells and flesh grant sasuke access to sage arts/chakra?
the cursed seal contained "automatic" elements that took care of "sensing" and the juugo elements that took care of "gathering and processing"
at this point, sasuke need only to gain awareness of natural energy, to sense it but then gathering and processing will be advantageous because of juugo's cells.
this could still impact sasuke in a big way since the story went out of it's way to skirt the uzumaki aside and perform a critical healing in such an arbitrary one-off style at that time.
im predicting juugo's cells will link sasuke to the jyubi in a much more effective manner than madara and obito's mokuton "leash".
Here's a question that I've been thinking about lately: is it possible that the Uzumaki clan are the true descendants of the Younger Son, and not the Senju clan? I mean, yeah, Hashirama had his Mokuton jutsu, and was incredibly powerful. But it seems to me that the Uzumaki clan in general has more amazing abilities. All of them were renown for possessing huge chakra pools and longer than normal lifespans. They also seem to unique chakra abilities as well: Karin has her unique healing ability, Kushina had her chakra chains which she used to contain the Kyuubi, Mito was such a powerful sensor she could locate people by their emotions. It just seems to me that they have more power overall than the Senju clan did, aside from Hashirama.